| Strikeouts | |||
| Players | Teams | SO | IP |
| Clemens, R | BOB | 336 | 294.1 |
| Martinez, PJ | KHK | 286 | 287.0 |
| Schilling, C | BOB | 275 | 267.2 |
| Johnson, R | JB | 263 | 263.0 |
| Cone, D | KEN | 243 | 228.1 |
| Mussina, M | KEN | 227 | 247.0 |
| Brown, K | CCK | 224 | 245.2 |
| Kile, D | SPS | 214 | 254.0 |
| Neagle, D | GRN | 202 | 256.1 |
| Smoltz, J | GRN | 197 | 242.0 |