| Strikeouts | |||
| Players | Teams | SO | IP |
| Clemens, R | DB-JH | 279 | 243.2 |
| Johnson, R | GH | 273 | 248.1 |
| Maddux, G | KHK | 267 | 293.0 |
| Martinez, P | BT | 243 | 255.1 |
| Schilling, C | BOB | 237 | 226.1 |
| Mussina, M | GN | 228 | 221.2 |
| Leiter, A | GN | 226 | 256.0 |
| Brown, K | CK | 219 | 266.1 |
| Reynolds, S | KRK | 206 | 230.0 |
| Finley, C | DB | 198 | 222.2 |